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Italic type (cut by Francesco Griffo) is first used by Aldus Manutius at the Aldine Press in Venice, in an edition of Virgil.
https://en.wikipedia.org/wiki/1501
A Greek and Italian parallel text edition of Herodotus' Histories done for Count Matteo Maria Boiardo is published in Venice by Aldus Manutius.
https://en.wikipedia.org/wiki/1502
https://en.wikipedia.org/wiki/1504